A framework for the biophysical screening of antibody mutations targeting solvent-accessible hydrophobic and electrostatic patches for enhanced viscosity profiles-Reference-Cited by-同舟云学术

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A framework for the biophysical screening of antibody mutations targeting solvent-accessible hydrophobic and electrostatic patches for enhanced viscosity profiles

Published:2024-12 Issue: Volume:23 Page:2345-2357
ISSN:2001-0370
Container-title:Computational and Structural Biotechnology Journal
language:en
Short-container-title:Computational and Structural Biotechnology Journal

Author:

Armstrong Georgina B.,Shah Vidhi,Sanches Paula,Patel Mitul,Casey Ricky,Jamieson Craig,Burley Glenn A.,Lewis William,Rattray Zahra

Funder

Biotechnology and Biological Sciences Research Council

GlaxoSmithKline

Engineering and Physical Sciences Research Council

Publisher

Elsevier BV

Reference46 articles.

1. Development of therapeutic antibodies for the treatment of diseases;Lu;J Biomed Sci,2020

2. A systematic review of commercial high concentration antibody drug products approved in the US: formulation composition, dosage form design and primary packaging considerations;Ghosh;mAbs,2023

3. Ongoing challenges to develop high concentration monoclonal antibody-based formulations for subcutaneous administration: quo vadis?;Jiskoot;J Pharm Sci,2022

4. Predicting antibody developability profiles through early stage discovery screening;Bailly;MAbs,2020

5. The search for novel proline analogs for viscosity reduction and stabilization of highly concentrated monoclonal antibody solutions;Prašnikar;Int J Pharm,2024

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