Force-dependent trans-endocytosis by breast cancer cells depletes costimulatory receptor CD80 and attenuates T cell activation

Author:

Park Seungman,Shi Yu,Kim Byoung Choul,Jo Myung Hyun,Cruz Leilani O.,Gou Zheming,Ha Taekjip,Lu Li-Fan,Reich Daniel H.,Chen Yun

Funder

Johns Hopkins University Startup Fund

Maryland Stem Cell Research Fund

National Research Foundation of Korea

Ministry of Education

Publisher

Elsevier BV

Subject

Electrochemistry,Biomedical Engineering,General Medicine,Biophysics,Biotechnology

Reference58 articles.

1. T-cell regulation by CD28 and CTLA-4;Alegre;Nat. Rev. Immunol.,2001

2. The role of endocytosis in activating and regulating signal transduction;Andersson;Cell. Mol. Life Sci.,2012

3. Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous;Bachmann;J. Immunol.,1999

4. Positive and negative regulation of human T cell activation mediated by the CTLA-4/CD28 ligand CD80;Boulougouris;J. Immunol.,1998

5. Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/B7 family;Bour-Jordan;Immunol. Rev.,2011

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