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NLRP3 inflammasome activation in mesenchymal stem cells inhibits osteogenic differentiation and enhances adipogenic differentiation

  • Published:2017-03 Issue:4 Volume:484 Page:871-877
  • ISSN:0006-291X
  • Container-title:Biochemical and Biophysical Research Communications
  • language:en
  • Short-container-title:Biochemical and Biophysical Research Communications

Author:

Wang Linghao,Chen Ke,Wan Xinxing,Wang Fang,Guo Zi,Mo Zhaohui

Funder

Science and Technology Project of Hunan Province

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference30 articles.

1. Osteoporosis: the result of an 'aged' bone microenvironment;Yu;Trends Mol. Med.,2016

2. Mechanical strain regulates osteogenic and adipogenic differentiation of bone marrow mesenchymal stem cells;Li;Biomed. Res. Int.,2015

3. Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis;Takada;Nat. Rev. Rheumatol.,2009

4. Pharmacological inhibition of PPARgamma increases osteoblastogenesis and bone mass in male C57BL/6 mice;Duque;J. Bone Min. Res.,2013

5. Mechanisms of disease: is osteoporosis the obesity of bone?;Rosen;Nat. Clin. Pract. Rheumatol.,2006
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