Number Needed to Treat and Number Needed to Harm analysis of the zuranolone phase 2 clinical trial results in major depressive disorder

Author:

Arnaud AlixORCID,Suthoff EllisonORCID,Stenson KatieORCID,Werneburg Brian,Hodgkins Paul,Bonthapally Vijayveer,Jonas Jeffrey,Meyer Kellie,O'Day Ken

Funder

SAGE Therapeutics Inc

Publisher

Elsevier BV

Subject

Psychiatry and Mental health,Clinical Psychology

Reference66 articles.

1. Neurosteroids promote phosphorylation and membrane insertion of extrasynaptic GABAA receptors;Abramian;Proc Natl Acad Sci U S A,2014

2. Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator;Althaus;Neuropharmacology,2020

3. Diagnostic and statistical manual of mental disorders,2013

4. Antidepressants versus placebo for depression in primary care;Arroll;Cochrane Database of Systematic Reviews,2009

5. Modifiable risk factors predicting major depressive disorder at four year follow-up: a decision tree approach;Batterham;BMC Psychiatry,2009

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