Author:
Karelin Andrei A,Blishchenko Elena Yu,Ivanov Vadim T
Abstract
Systematic analysis of structure and biological activity of peptide components of tissue extracts and biological fluids allows us to formulate a novel concept of a peptidergic regulatory system, complementary to the conventional regulatory systems (i.e. nervous, endocrine and paracrine systems). According to that concept, the proteolytic degradation of tissue proteins carried out by a specific and regulated system of tissue‐specific enzymes and protein substrates gives rise to a large group of peptides, which we define as tissue‐specific peptide pool. As a result, functional proteins provide their proteolytically derived fragments for maintaining tissue homeostasis.
Reference54 articles.
1. Papsuevich O.S. Chipens G.I. and Mikhailova S.V. (1986) Neurohypophysial Hormones Zinatne Riga (in Russian).
2. CNS effects of peptides: A cross-listing of peptides and their central actions published in the journal Peptides, 1986–1993
3. Siddle K. and Hutton J.C. (1994) Mechanisms of Hormone Action Oxford University Press Oxford.
Cited by
44 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献