Author:
Blázquez Cristina,Geelen Math J.H,Velasco Guillermo,Guzmán Manuel
Abstract
Fatty acids induce apoptosis in primary astrocytes by enhancing ceramide synthesis de novo. The possible role of the AMP‐activated protein kinase (AMPK) in the control of apoptosis was studied in this model. Long‐term stimulation of AMPK with 5‐aminoimidazole‐4‐carboxamide ribonucleoside (AICAR) prevented apoptosis. AICAR blunted fatty acid‐mediated induction of serine palmitoyltransferase and ceramide synthesis de novo, without affecting fatty acid synthesis and oxidation. Prevention of ceramide accumulation by AICAR led to a concomitant blockade of the Raf‐1/extracellular signal‐regulated kinase cascade, which selectively mediates fatty acid‐induced apoptosis. Data indicate that AMPK may protect cells from apoptosis induced by stress stimuli.
Cited by
155 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献