Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis

Author:

Yang Qining,Wang Changyuan,Jin Yue,Ma Xiaodong,Xie Tianqi,Wang Jiaying,Liu Kexin,Sun Huijun

Funder

Chinese National Natural Science Foundation

Science Foundation of Science & Technology Bureau of Liaoning Province

Publisher

Elsevier BV

Subject

Pharmacology

Reference48 articles.

1. Chemokines: inflammatory mediators of atherosclerosis;Liehn;Arch. Physiol. Biochem.,2006

2. Lipid homeostasis in macrophages - implications for atherosclerosis. Reviews of physiology;Schmitz;Biochem. Pharmacol.,2008

3. An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E(-)/(-) mice;Meng;Sci. Rep.,2014

4. Nonmuscle myosin light-chain kinase deficiency attenuates atherosclerosis in apolipoprotein E-deficient mice via reduced endothelial barrier dysfunction and monocyte migration;Sun;Circulation,2011

5. Gene Transfers of Vascular Endothelial Growth Factor-A, Vascular Endothelial Growth Factor-B, Vascular Endothelial Growth Factor-C, and Vascular Endothelial Growth Factor-D Have No Effects on Atherosclerosis in Hypercholesterolemic Low-Density Lipoprotein-Receptor/Apolipoprotein B48-Deficient Mice

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