Bimekizumab for patients with moderate to severe plaque psoriasis: 60-week results from BE ABLE 2, a randomized, double-blinded, placebo-controlled, phase 2b extension study

Author:

Blauvelt Andrew,Papp Kim A.,Merola Joseph F.,Gottlieb Alice B.,Cross Nancy,Madden Cynthia,Wang Maggie,Cioffi Christopher,Griffiths Christopher E.M.

Funder

UCB

Publisher

Elsevier BV

Subject

Dermatology

Reference20 articles.

1. IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding;Hymowitz;EMBO J,2001

2. Bimekizumab dual inhibition of IL-17A and IL-17F provides evidence of IL-17F contribution to chronic inflammation in disease-relevant cells;Maroof;Ann Rheum Dis,2017

3. IL-17F contributes to human chronic inflammation in synovial tissue: preclinical evidence with dual IL-17A and IL-17F inhibition with bimekizumab in psoriatic arthritis;Maroof;Ann Rheum Dis,2017

4. Heterogeneous expression pattern of interleukin 17A (IL-17A), IL-17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for nonresponse to anti-IL-17 therapy?;van Baarsen;Arthritis Res Ther,2014

5. Functional characterization of IL-17F as a selective neutrophil attractant in psoriasis;Watanabe;J Invest Dermatol,2009

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