Pluronic block copolymers alter apoptotic signal transduction of doxorubicin in drug-resistant cancer cells

Author:

Minko Tamara,Batrakova Elena V.,Li Shu,Li Yili,Pakunlu Refika I.,Alakhov Valery Yu.,Kabanov Alexander V.

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference40 articles.

1. Hypersensitizing effect of pluronic L61 on cytotoxic activity, transport, and subcellular distribution of doxorubicin in multiple drug-resistant cells;Venne;Cancer Res.,1996

2. Mechanism of sensitization of MDR cancer cells by Pluronic block copolymers: selective energy depletion;Batrakova;Br. J. Cancer,2001

3. Pluronic block copolymers for overcoming drug resistance in cancer;Kabanov;Adv. Drug Deliv. Rev.,2002

4. Optimal structure requirements for pluronic block copolymers in modifying P-glycoprotein drug efflux transporter activity in bovine brain microvessel endothelial cells;Batrakova;J. Pharmacol. Exp. Ther.,2003

5. Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP1049C) in patients with advanced cancer;Danson;Br. J. Cancer,2004

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