Nanoformulation of CCL21 greatly increases its effectiveness as an immunotherapy for neuroblastoma

Author:

Poelaert Brittany J.,Romanova Svetlana,Knoche Shelby M.,Olson Madeline T.,Sliker Bailee H.,Smits Kaitlin,Dickey Brittney L.,Moffitt-Holida Alexandra E.J.,Goetz Benjamin T.,Khan Nuzhat,Smith Lynette,Band Hamid,Mohs Aaron M.,Coulter Donald W.,Bronich Tatiana K.,Solheim Joyce C.

Funder

UNMC Pediatric Cancer Research Center

UNMC Fred & Pamela Buffett Cancer Center Support Grant

UNMC Graduate Studies Fellowships

Cancer Biology Training Grant

Center for Biomedical Research Excellence (CoBRE) Nebraska Center for Nanomedicine

Institutional Development Award from the U.S. National Institute of General Medical Sciences

Nebraska Research Initiative

NRI

University of Nebraska Foundation

Fred & Pamela Buffett Cancer Center's U.S. National Cancer Institute Cancer Center Support Grant

Nebraska Banker's Fund and by the U.S. NIH-NCRR Shared Instrument Program

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference87 articles.

1. CCL21 induces extensive intratumoral immune cell infiltration and specific anti-tumor cellular immunity;Turnquist;Int. J. Oncol.,2007

2. CCL21 is an effective surgical neoadjuvant for treatment of mammary tumors;Ashour;Cancer Biol. Ther.,2007

3. Secondary lymphoid tissue chemokine reduces pulmonary tumor burden in spontaneous murine bronchoalveolar cell carcinoma;Sharma;Cancer Res.,2001

4. The dynamics of the T-cell antitumor response: chemokine-secreting dendritic cells can prime tumor-reactive T cells extranodally;Kirk;Cancer Res.,2001

5. Chemokines: can effector cells be redirected to the site of the tumor?;Dubinett;Cancer J.,2010

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