The neuroprotective effect of schisandrol A on 6-OHDA-induced PD mice may be related to PI3K/AKT and IKK/IκBα/NF-κB pathway

Author:

Yan Tingxu,Sun Yingying,Gong Guowei,Li Yue,Fan Kaiyue,Wu Bo,Bi Kaishun,Jia Ying

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Cell Biology,Endocrinology,Genetics,Molecular Biology,Ageing,Biochemistry

Reference54 articles.

1. Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease;Abdul,2007

2. Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome;Afonina;Nat. Immunol.,2017

3. Schisandrin B shows neuroprotective effect in 6-OHDA-induced Parkinson’s disease via inhibiting the negative modulation of miR-34a on Nrf2 pathway;Ba;Biomed. Pharmacother.,2015

4. Glycogen synthase kinase 3β (GSK3β) mediates 6-hydroxydopamine-induced neuronal death;Chen;FASEB J.,2004

5. Neuroprotective and neuro-restorative effects of minocycline and rasagiline in a zebrafish 6-hydroxydopamine model of Parkinson’s disease;Cronin;Neuroscience,2017

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