Development and validation of an UPLC-MS/MS method for the determination of irinotecan (CPT-11), SN-38 and SN-38 glucuronide in human plasma and peritoneal tumor tissue from patients with peritoneal carcinomatosis

Author:

Gasthuys Elke,van Ovost Judith,Vande Casteele Sofie,Cosyns Sarah,Ceelen Wim,Van Bocxlaer Jan,Vermeulen An

Funder

Kom op tegen Kanker

Publisher

Elsevier BV

Subject

Cell Biology,Clinical Biochemistry,Biochemistry,General Medicine,Analytical Chemistry

Reference23 articles.

1. A new UPLC-MS/MS method for the determination of irinotecan and 7-ethyl-10-hydroxycamptothecin (SN-38) in mice: application to plasma and brain pharmacokinetics;Goldwirt;J. Pharm. Biomed. Anal.,2012

2. Population pharmacokinetics of CPT-11 (irinotecan) in gastric cancer patients with peritoneal seeding after its intraperitoneal administration;Ahn;Eur. J. Clin. Pharmacol.,2010

3. Current perspectives on the clinical experience, pharmacology, and continued development of the camptothecins;Garcia-Carbonero;Clin. Can. Res. off. J. Am. Assoc. Can. Res.,2002

4. Clinical pharmacokinetics and metabolism of irinotecan (CPT-11);Mathijssen;Clin. Can. Res. Off. J. Am. Assoc. Can. Res.,2001

5. Human carboxylesterases: a comprehensive review;Wang;Acta Pharm. Sin. B,2018

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