The lipopolysaccharide biosynthesis locus of Campylobacter jejuni 81116-Reference-Cited by-同舟云学术

The lipopolysaccharide biosynthesis locus of Campylobacter jejuni 81116

Published:1998-08-01 Issue:8 Volume:144 Page:2049-2061
ISSN:1350-0872
Container-title:Microbiology
language:en
Short-container-title:

Author:

Fry Ben N.¹,Korolik Victoria²,ten Brinke Janna A¹,Pennings Maarten T. T²,Zalm Robert¹,Teunis Bart J. J¹,Coloe Peter J.²,van der Zeijst Bernard A. M¹

Affiliation:

1. Department of Bacteriology, Institute of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht UniversityYalelaan 1, 3584 CL UtrechtThe Netherlands

2. Department of Applied BiologyRMIT GPO Box 2476V, Melbourne 3001Australia

Abstract

MostCampylobacter jejunistrains express lipo-oligosaccharides. Some strains also express lipopolysaccharides (LPS), with O-antigen-like carbohydrate repeats.C. jejuni81116 expresses an LPS containing both lipo-oligosaccharides and O-antigen-like repeats, but nothing is known about the structure or sugar composition of these LPS species. A cosmid library of the genome of C.jejuni81116 was constructed and probed withCampylobacter hyoileigenes involved in LPS synthesis. Five cosmids hybridized with the probe and two of these expressed C.jejuni81116 LPS inEscherichia coli. By subcloning, a 16 kb DNA region was identified which contains the genetic information required to express C.jejuniLPS. DNA sequence analysis revealed 11 ORFs homologous to genes involved in LPS synthesis of other bacteria. They consisted of three homologues of sugar biosynthesis genes, two homologues of transport genes and six homologues of sugar transferases.

Publisher

Microbiology Society

Subject

Microbiology

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