Nasopharyngeal carriage and antimicrobial susceptibility profiles of Streptococcus pneumoniae among children with pneumonia and healthy children in Padang, Indonesia

Author:

Yani Finny Fitry12,Julianty Riris Juita12,Tafroji Wisnu3,Linosefa Linosefa4,Ihsan Indra12,Masnadi Nice Rachmawati12,Safari Dodi3ORCID

Affiliation:

1. Departement of Paediatric, Dr. M. Djamil Hospital Padang, Kota Padang, Indonesia

2. Departement of Child Health, Faculty of Medicine, Universitas Andalas, Padang, Indonesia

3. Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, West Java, Indonesia

4. Departement of Microbiology, Faculty of Medicine, Universitas Andalas, Padang, Indonesia

Abstract

Streptococcus pneumoniae is one of the pathogenic bacteria causing invasive pneumococcal diseases such as pneumonia, sepsis, and meningitis, which are commonly reported in children and adults. In this study, we investigated the nasopharyngeal carriage rates, serotype distribution, and antimicrobial susceptibility profiles of S. pneumoniae among children with pneumonia and healthy children under 5 years old in Padang, West Sumatra, Indonesia. Nasopharyngeal swabs were collected from 65 hospitalized children with pneumonia in a referral hospital and from 65 healthy children at two day-care centers from 2018 to 2019. S. pneumoniae was identified by conventional and molecular methods. Antibiotic susceptibility was performed with the disc diffusion method. Out of 130 children, S. pneumoniae strains were carried by 53% and 9.2 % in healthy children (35/65) and children with pneumonia (6/65), respectively. Serotype 19F was the most common serotype among the isolated strains (21%) followed by 6C (10%), 14, 34 (7 % each), and 1, 23F, 6A, 6B (5 % each). Moreover, 55 % of the strains (23/42) were covered by the 13-valent pneumococcal conjugate vaccine. Most isolates were susceptible to vancomycin (100%), chloramphenicol (93%), clindamycin (76%), erythromycin (71%), and tetracycline (69%). Serotype 19F was commonly found as a multi-drug resistant strain.

Funder

Fundamental Grant Ministry of Education & Technology

Publisher

Microbiology Society

Subject

Microbiology (medical),Microbiology

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