Targeting novel structural and functional features of coronavirus protease nsp5 (3CLpro, Mpro) in the age of COVID-19-Reference-Cited by-同舟云学术

Targeting novel structural and functional features of coronavirus protease nsp5 (3CLpro, Mpro) in the age of COVID-19

Published:2021-03-01 Issue:3 Volume:102 Page:
ISSN:0022-1317
Container-title:Journal of General Virology
language:en
Short-container-title:

Author:

Roe Molly K.¹,Junod Nathan A.¹^ORCID,Young Audrey R.¹,Beachboard Dia C.²^ORCID,Stobart Christopher C.¹^ORCID

Affiliation:

1. Department of Biological Sciences, Butler University, Indianapolis, IN, USA

2. Department of Biology, DeSales University, Center Valley, PA, USA

Abstract

Coronavirus protease nsp5 (M pro , 3CL pro ) remains a primary target for coronavirus therapeutics due to its indispensable and conserved role in the proteolytic processing of the viral replicase polyproteins. In this review, we discuss the diversity of known coronaviruses, the role of nsp5 in coronavirus biology, and the structure and function of this protease across the diversity of known coronaviruses, and evaluate past and present efforts to develop inhibitors to the nsp5 protease with a particular emphasis on new and mostly unexplored potential targets of inhibition. With the recent emergence of pandemic SARS-CoV-2, this review provides novel and potentially innovative strategies and directions to develop effective therapeutics against the coronavirus protease nsp5.

Publisher

Microbiology Society

Subject

Virology

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