ICTV Virus Taxonomy Profile: Hepadnaviridae

Author:

Magnius Lars1,Mason William S.2,Taylor John2,Kann Michael3,Glebe Dieter4,Dény Paul5,Sureau Camille6,Norder Heléne3,

Affiliation:

1. Ulf Lundahl´s Foundation, 10061 Stockholm, Sweden

2. Fox Chase Cancer Center, Philadelphia, PA 19111, USA

3. Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, Sweden

4. Institute of Medical Virology, National Reference Centre for Hepatitis B and D Viruses, Justus-Liebig-University Giessen, German Centre for Infection Research (DZIF), Giessen, Germany

5. Centre de Recherches en Cancérologie de Lyon, INSERM U1052, UMR CNRS 5286, Team Hepatocarcinogenesis and Viral Infection, Lyon, France

6. Institut National de la Transfusion Sanguine (INTS), CNRS-INSERM U1134, Paris, France

Abstract

The family Hepadnaviridae comprises small enveloped viruses with a partially double-stranded DNA genome of 3.0–3.4 kb. All family members express three sets of proteins (preC/C, polymerase and preS/S) and replication involves reverse transcription within nucleocapsids in the cytoplasm of hepatocytes. Hepadnaviruses are hepatotropic and infections may be transient or persistent. There are five genera: Parahepadnavirus, Metahepadnavirus, Herpetohepadnavirus, Avihepadnavirus and Orthohepadnavirus. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the family Hepadnaviridae, which is available at ictv.global/report/hepadnaviridae.

Funder

Wellcome Trust

Publisher

Microbiology Society

Subject

Virology

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