Dengue Virus Gene-Silencing Techniques: A Current Assessment

Abstract

Infection with the Dengue virus (DENV) has become a global threat, affecting approximately 100 nations. There is not a recognized antiviral treatment for dengue at the moment. Therefore, it is crucial to create therapeutic approaches to treat this fatal condition. A critical and successful method of silencing genes, RNA interference breaks down targeted RNA according to its sequence. Over the past ten years, a number of studies have been carried out to determine how well siRNA works to prevent dengue virus replication. CRISPR (clustered regularly interspaced short palindromic repeats) is becoming one of the most effective and widely used tools for RNA and DNA manipulation in numerous organisms. In our review, we describe and discuss the use of these technologies to comprehend and treat DENV-related infections.