Author:
Álvarez-Lorenzo Sofia,Elizabeth Montalvo-Castro Rebeca,Jiménez-López Jeannie,Adriana Medina-Mondragón María,Salinas-Jazmín Nohemí
Abstract
Breast cancer is one of the most aggressive diseases in women, responsible for thousands of deaths annually and millions of new diagnoses; its treatment presents multiple obstacles due to late diagnosis and the various mechanisms of tumor resistance. In breast cancer the membrane-bound complement regulatory proteins (mCRP) have been proposed as biomarkers of malignant cellular transformation. These are molecules capable of inhibiting therapeutic efficacy, from both antibodies and cytotoxic drugs. Therefore, these proteins are potential targets to increase therapeutic efficacy and avoid cancer progression. We will gather information about mCRP: (i) structural features; (ii) expression levels in breast cancer and relationship with prognosis; (iii) therapeutic resistance mechanisms; and (iv) strategies to down-regulate mCRP in both activity and expression.
Reference97 articles.
1. Kashyap D, Pal D, Sharma R, Garg VK, Goel N, Koundal D, et al. Global increase in breast cancer incidence: Risk factors and preventive measures. BioMed Research International. 2022;2022:1-16. DOI: 10.1155/2022/9605439
2. Vučković L, Klisic A, Raonić J, Vućinić J. Comparative study of immunohistochemical determination of breast cancer molecular subtypes on Core biopsy and surgical specimens. European Review for Medical and Pharmacological Sciences. 2021;25:3990-3996. DOI: 10.26355/eurrev_202106_26039
3. Hammerl D, Smid M, Timmermans AM, Sleijfer S, Martens JWM, Debets R. Breast cancer genomics and immuno-oncological markers to guide immune therapies. Seminars in Cancer Biology. 2018;52:178-188. DOI: 10.1186/s12943-017-0621-z
4. Waks AG, Winer EP. Breast cancer treatment: A review. JAMA. 2019;321:288-300. DOI: 10.1001/JAMA.2018.19323
5. Kerr AJ, Dodwell D, McGale P, Holt F, Duane F, Mannu G, et al. Adjuvant and neoadjuvant breast cancer treatments: A systematic review of their effects on mortality. Cancer Treatment Reviews. 2022;105:1-12. DOI: 10.1016/j.ctrv.2022.102375