The Potential of Human Induced Pluripotent Stem Cells (hiPSCs) for the Study of Channelopathies: Advances and Future Directions

Abstract

Human induced pluripotent stem cells (hiPSCs) have revolutionized research on ion channels and channelopathies. Channelopathies are a group of genetic disorders characterized by dysfunctional ion channels, which are responsible for the regulation of ion flow across cell membranes. These disorders can affect various organ systems, leading to a wide range of symptoms and clinical manifestations. Differentiating pluripotent stem cells into various cell types results in the possibility of creating tissue- and disease-specific cell models. These models offer the possibility to investigate the underlying mechanisms of channelopathies and develop potential therapies. Using hiPSC-derived cells has allowed crucial insights into diseases like epilepsy, long QT syndrome, and periodic paralysis. However, the full potential of hiPSCs in this field is still to be exploited. The research will most likely focus on developing more complex cell models to further investigate channel dysfunction and its pathological consequences. In addition, hiPSCs will be increasingly used in drug screening and developing personalized therapies for various diseases. This chapter outlines the past and present achievements of hiPSCs in the field of channelopathies as well as provides an outlook on future possibilities.