Abstract
Colorectal cancer (CRC) is the third most common cancer worldwide in 2020. Screening is especially suitable for colorectal cancer (CRC), given its prevalence and the belief that it represents a progressive adenoma-carcinoma chain. In developing nations, CRC screening is occasionally opportunistic; it is sometimes detected concurrently with other symptoms. There are several simple screening methods available such as digital rectal examination and fecal occult blood test (FOBT). Furthermore, the more advance screening method endoscopic, stoll-based, or radiological, blood-based screening also available. But in the developing countries, that options are limited due to lack of data, knowledge, awareness, human resources, infrastructure, screening guidelines, and cost issue. To overcome that challenge, technological development, policy updates, and the right screening choice can be effective in that setting.