Analysis of Biochemical and Histological Indicators in the Blood Serum and Organs of Rats during Prolonged Oral Administration of Food Additive E 102 (Tartrazine)

Abstract

The food azo dye tartrazine (Е102) is not metabolized in humans, and it is excreted unchanged through the kidneys. A study was carried out on the biochemical and histological features in the kidneys of rats, as well as the biochemical features in the blood and urine during long-term use of tartrazine E102 (1 ml of 0.1% solution per 100 g of animal weight daily). In the first experiment, animals received a solution of tartrazine from 1 month up to 3 months age per os; in the second experiment, individuals received tartrazine first transplacentally (in utero), then with mother’s milk, and during 1 month only with food. In the animals of the first experiment, the biochemical changes are not profound, and it is morphologically shown that the losses of the parenchyma and stroma of the kidney are compensated and regenerated. In the second experiment, oxidative stress and signs of chronic glomerulonephritis and chronic tubulointerstitial nephritis were detected against the background of disorders of intrauterine kidney development.