Abstract
The regeneration of skin because of numerous sorts of injuries such as burns, wounds, tissue damage, and eczema is regarded as vital; nevertheless, the process of healing and remodeling can be impeded by several reasons. The cutting-edge of nanofibrous technology offers the opportunity to repurpose and innovate new therapies and improve the effectiveness of the available medical treatments. There may be less need for skin transplants and skin grafts as regenerative medicine advances using biopolymeric materials. Skin injuries can be difficult to treat, especially when it comes to managing wounds. The fabrication of different dosage forms such as film, foam, sponge, hydrogel, and nanofiber membranes using scaffolding material made from synthetic and natural polymers is considered a treatment method for wounds. Scaffolds have found applicability in tissue engineering, where the materials are fabricated into artificial tissue that stimulates growth factors and enhances tissue regeneration. Among these materials, nanofibers possess a unique structure of small pore size and high porosity, thus protecting wounds from infections and ensuring unrestricted transportation of gas and liquid molecules. We have described several polymers in this study that have been used to create scaffolds made of electrospun nanofibers. These scaffolds are studied and discussed using different polymers to show the effect on skin repair mechanisms and investigate the remodeling abilities aiming to potentially show a foundation for clinical applications and industrial manufacturing. The extracellular matrix (ECM) and the nanofiber structure share many similarities, and the use of different types of polymers, including biopolymers like collagen and chitosan and biodegradable polymers like polycaprolactone, polylactic acid, and polyvinyl alcohol, helps to make the field relevant to skin regeneration and remodeling. Hence, this review summarized and discussed the polymeric nanofibers such as collagen, polycaprolactone, poly vinyl alcohol reporting pre-clinical trials of wound healing and skin regeneration.