Abstract
This overview was evaluated by the development of diabetic retinopathy (DR) and the stem cell therapy approach. DR is a microvascular complication of diabetes mellitus, characterized by damage to the retinal blood vessels leading to progressive loss of vision. However, the pathophysiological mechanisms are complicated and not completely understood yet. The current treatment strategies have included medical, laser, intravitreal, and surgical approaches. It is known that the use of mesenchymal stem cells (MSC), which has a great potential, is promising for the treatment of many degenerative disorders, including the eye. In retinal degenerative diseases, MSCs were ameliorated retinal neurons and retinal pigmented epithelial cells in both in vitro and in vivo studies. Stem cell therapies show promise in neurodegenerative diseases. However, it is very important to know which type of stem cell will be used in which situations, the amount of stem cells to be applied, the method of application, and its physiological/neurophysiological effects. Therefore, it is of great importance to evaluate this subject physiologically. After stem cell application, its safety and efficacy should be followed for a long time. In the near future, widespread application of regenerative stem cell therapy may be a standard treatment in DR.
Reference51 articles.
1. Sevil K. The Effect of Mesenchymal Stem Cell Applications on Diabetes and Tamoxifen Retinopathy in Diabetic Rats. Kayseri, Turkey: Erciyes University; 2020
2. Trapani I, Puppo A, Auricchio A. Vector platforms for gene therapy of inherited retinopathies. Progress in Retinal and Eye Research. 2014;43:108-128. DOI: 10.1016/j.preteyeres.2014.08.001
3. Galderisi U, Peluso G, Di Bernardo G. Clinical trials based on mesenchymal stromal cells are exponentially increasing: Where are we in recent years? Stem Cell Reviews and Reports. 2021;17(4):1-14. DOI: 10.1007/s12015-021- 10231-w
4. Bassi R, Trevisani A, Tezza S, Ben Nasr M, Gatti F, Vergani A, et al. Regenerative therapies for diabetic microangiopathy. Experimental Diabetes Research. 2012;2012:916560. DOI: 10.1155/2012/916560
5. Mutlu S. The Effect of Exercise on Physical Profile and Some Physiological Parameters in Pregnant Women. Kayseri, Turkey: Erciyes University; 2019