Author:
Padilla-Raygoza Nicolás,Flores-Vargas Gilberto,de Jesús Gallardo-Luna María,Navarro-Olivos Efraín,Javier Magos-Vázquez Francisco,Alberto Díaz-Martínez Daniel
Abstract
In late 2019, pneumonia cases from unknown origin were detected in Wuhan, China. The cause was a new coronavirus. The World Health Organization (WHO) named the virus SARS-CoV-2 and COVID-19 the associated disease. In the first months of 2020, this disease became a pandemic with a high lethality reported. Since then, the search for treatments began. We started by searching among treatments previously approved for human use that were not designed for COVID-19 and were considered to treat this condition. We continued searching on the therapeutics guidelines published by the WHO for the management of infection by SARS-CoV-2. Based on these results, we searched for the literature in PubMed to obtain further evidence on the drugs against SARS-CoV-2. The treatments presented in this chapter are Ivermectin, Hydroxychloroquine, Nitazoxanide, Azithromycin, Molnupiravir, Casirivimab-Imdevimab, Ritonavir-Nirmatrelvir, Ritonavir-Lopinavir, Remdesivir, and Favipiravir. Two years ahead of the start of the COVID-19 pandemic, a plenty of options for treatment have been investigated. Only a few of them have been shown to be efficient and safe. According to the WHO, Ritonavir-Nirmatrelvir outperforms other proposed therapeutics.
Reference54 articles.
1. World Health Organization. Rolling updates on coronavirus disease (COVID-19). World Health Organization. 2020. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/events-as-they-happen. [Accessed: May 2, 2022]
2. Carlos WG, De la Cruz C, Cao B, Pasnick S, Jamil S. Novel Wuhan (2019-CoV) coronavirus. American Journal of Respiratory and Critical Care Medicine. 2020;201(4):7-8. DOI: 10.1164/rccm.2014P7
3. Harrison AG, Lin T, Wang P. Mechanisms of SARS-CoV-2 transmission and pathogenesis. Trends in Immunology. 2020;41(12):1100-1115. DOI: 10.1016/j.it.2020.10.004
4. Sheahan TP, Sims AC, Zhou S, Graham RL, Pruijssers AJ, Agostini ML, et al. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Science Translational Medicine. 2020;12:1-15. DOI: 10.1126/scitranslmed.abb5883
5. Chan LYH, Yuan B, Convertino M. COVID-19 non-pharmaceutical intervention portfolio effectiveness and risk communication predominance. Scientific Reports. 2021;11(1):1-17. DOI: 10.1038/s41598-021-88309-1