Abstract
Nutrition: a natural and promising option in colorectal cancer intervention Nutrition plays a significant role in the intervention of colorectal cancer (CRC) by decreasing the risks of colorectal carcinogenesis. Products from both plant and animal origins have been involved in the prevention and/or treatment of CRC. Intake of dietary products including fibre-rich foods, nutraceuticals, wholegrains, dairy products, and limited consumption or avoidance of red/processed meat and alcohol could reduce the risk of CRC. These nutritional compounds, in CRC intervention, could be in form of folklore/alternative medicine or isolated compounds used in the production of many chemotherapeutic agents. Monitoring of individual’s nutritional status could serve as a possible preventive or therapeutic measure against CRC, majorly by interaction with intestinal microbiota, thereby potentiating host anti-cancer immune response and/or interfering with mechanisms of carcinogenesis.
Reference57 articles.
1. Dekker E, Tanis PJ, Vleugels JLA, Kasi PM, Wallace MB. Colorectal cancer. The Lancet. 2019;394(10207):1467-1480. DOI: 10.1016/S0140-6736(19)32319-0
2. Irabor D. Emergence of colorectal cancer in West Africa: Accepting the inevitable. South African Gastroenterology Review. 2017;15(1):11-16
3. Veettil SK, Wong TY, Loo YS, Playdon MC, Lai NM, Giovannucci EL, et al. Role of diet in colorectal cancer incidence: umbrella review of meta-analyses of prospective observational studies. JAMA Network Open. 2021;4(2):e2037341. DOI: 10.1001/jamanetworkopen.2020.37341
4. Chapelle N, Martel M, Toes-Zoutendijk E, Barkun AN, Bardou M. Recent advances in clinical practice: Colorectal cancer chemoprevention in the average-risk population. Gut. 2020;69(12):2244. DOI: 10.1136/gutjnl-2020-320990
5. Ryan-Harshman M, Aldoori W. Diet and colorectal cancer: Review of the evidence. Canadian Family Physician Medecin de famille canadien. 2007;53(11):1913-1920