Author:
I. Stenberg Virgil,L. Baldwin Ann
Abstract
In 1992, the hypothalamus-pituitary-adrenal (HPA) axis was proposed to be the inflammation control system of the body. The cortisol pulse that emanates from this axis when activated is the inflammation gatekeeper that terminates short-term, beneficial inflammation at is due time. As the cortisol pulse weakens with age, injury and heredity, the termination becomes incomplete. Then, the residual short-term inflammation evolves into long-term, destructive inflammation within inflammation disorders. In support of the proposal, induced inflammation in normal rats causes a corticosterone pulse. If the proposal were correct, the inflammation disease solution would be to supplement the cortisol pulse at the proper time. Twenty-one (21) participants with rheumatoid arthritis entered a double-blind, crossover study using patient self-administered prednisone. The 18 completing the study averaged a record 75% symptom improvement with no significant side effects. Further, 2428 participants with 38 inflammation disorders entered an open study using patient self-administrated cortisol. The 2015 completing the study averaged 76% symptom improvement with no significant side effects.