Renal ischemia and hypoxia: Functional differences and possible clinical and therapeutic consequences.

Author:

Bipat Robbert,Steels Paul,Toelsie Jerry

Abstract

End stage kidney disease contributes to a huge burden on global health. Recent advances have shown that ischemic and hypoxic conditions may contribute to the progression of the disorder and that acute kidney injury may cause and aggravate the condition. Ischemia and hypoxia are two distinct conditions with different pathophysiological and structural consequences as proven in the brain and liver of rats. Until now, these differences have not been shown to exist in the kidney. In this study, we assess the possible functional differences in the outcome of ischemic and hypoxic stress on the kidney. For this purpose, we perfused isolated rabbit kidneys with their autologous blood and applied short periods of ischemia or hypoxia in separate series of experiments. The results showed that the kidneys exposed to hypoxic stress suffered more functional damage than those subjected to ischemia. This conclusion was based on a lower creatinine clearance and urine osmolality, and a higher fractional excretion of urea, sodium, and glucose in the hypoxia series of kidneys. Consequently, we recommend monitoring hypoxemic conditions closely and correcting the condition as soon as possible, since even for a short period it may already have deteriorating effects on the renal function.

Publisher

IntechOpen

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3