Cation-𝜋 Interaction as a Key Player in Healthcare: A Mini-Review-Reference-Cited by-同舟云学术

Cation-𝜋 Interaction as a Key Player in Healthcare: A Mini-Review

Published:2022-12-15 Issue: Volume:2022 Page:1-13
ISSN:2754-6306
Container-title:Digital Medicine and Healthcare Technology
language:
Short-container-title:DMHT

Author:

Bergsma Simon¹,Poulios Efthymios²,Charalampogiannis Nikolaos³,Andraws Odetta⁴,Achinas Spyridon¹

Affiliation:

1. Faculty of Science and Engineering, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands

2. 4th Department of Surgery, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Rimini 1, Chaidari, 12462 Athens, Greece

3. SLK Kliniken am Gesundbrunnen, Am Gesundbrunnen 20–26, 74078 Heilbronn, Germany

4. School of Social Studies, Hanze University of Applied Sciences, Zernikeplein 23, 9747 AS Groningen, The Netherlands

Abstract

The cation-𝜋 interaction is a non-covalent interaction with significant role in healthcare such as biochemical systems or molecular neurobiology. The cation-𝜋 interaction is regarded as a strong non-covalent interaction in aqueous solutions essential for ligand–protein interfaces and delivery of chemical drugs. Limited knowledge is available regarding the manufacturing of synthetic functional materials (i.e. self-healing hydrogels) by availing the cation-𝜋 interaction. This mini-review aims to provide a brief summary on the importance of the cation-𝜋 interaction for protein stability and describes the impact on the secondary structure of proteins. Furthermore, it examines the cation-𝜋 interaction in medical applications and its impact in a receptor ligand that applies to neurobiology.

Publisher

IntechOpen

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