THE EFFECT OF QUERCETIN ON SOME HEMATOLOGICAL PARAMETERS AGAINST BISPHENOL-A EXPOSURE IN STREPTOZOCIN-INDUCED RATS
Author:
KOÇAK Yılmaz1ORCID, OTO Gokhan2ORCID, ALPARSLAN Seray2ORCID
Affiliation:
1. VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ FAKÜLTESİ, FİZYOTERAPİ VE REHABİLİTASYON BÖLÜMÜ 2. VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, FARMAKOLOJİ ANABİLİM DALI
Abstract
Bisphenol-A (BPA) is an endocrine-disrupting environmental toxin widely used in the composition of plastics. Today, the widespread use of BPA in preserving and packaging food and beverages increases BPA exposure. Therefore, recent research has focused on the health effects of continuous exposure to BPA. This study aimed to investigate the protective effect of quercetin (QUE) on different hematologic variables in rats induced by the environmental toxin BPA and streptozocin (STZ). Wistar albino rats were administered BPA orally (p.o.) at 10 mg/kg and QUE intraperitoneally (i.p.) at 15 mg/kg for 14 days. STZ was administered subcutaneously (s.c.) in a single dose of 50 mg/kg at the beginning of the experiment. 72 rats were randomly selected for the experimental procedure and divided into 9 groups with 8 animals in each group. The groups were created as follows; Group 1: Control (Saline); Group 2: Corn oil (0.5 ml, solvent); Group 3: STZ (50 mg/kg); Group 4: BPA (10 mg/kg); Group 5: QUE (15mg/kg); Group 6: STZ (50 mg/kg) + QUE (15mg/kg); Group 7: BPA (10 mg/kg) + QUE (15mg/kg); Group 8: STZ (50 mg/kg) + BPA group (10 mg/kg); Group 9: STZ (50 mg/kg) + BPA (10 mg/kg) + QUE (15mg/kg). STZ and BPA-treated rats showed functional variability in all hematologic parameters. The combination of STZ and BPA significantly reduced erythrocytes, leukocytes, and their associated parameters. However, QUE treatment alone or in combination corrected the altered hematologic parameters. The results of this study demonstrated that exposure to BPA in combination with STZ may alter hematologic indices, while QUE may be a therapeutic agent to correct the altered blood profile.
Funder
Van Yuzuncu Yil University Scientific Research Projects Coordination Unit .
Publisher
Kütahya Dumlupinar Üniversitesi
Reference33 articles.
1. [1] Abraham, A., Chakraborty, P., Staples, C., van der Hoeven, N., Clark, K., Mihaich, E., Woelz, J., Hentges, S. (2018). Distributions of concentrations of bisphenol A in North American and European surface waters and sediments determined from 19 years of monitoring data. Chemosphere, 201(8), 448–458. 2. [2] Hwang, M., Park, S.-J., and Lee, H.-J. (2023). Risk assessment of bisphenol a in the korean general population. Applied Sciences, 13(6), 3587. 3. [3] Ma, Q., Deng, P., Lin, M., Yang, L., Li, L., Guo, L., Zhang, L., He, M., Lu, Y., Pi, H., Zhang, Y., Yu, Z., Chen, C., and Zhou, Z. (2021). Long-term bisphenol-A exposure exacerbates diet-induced prediabetes via TLR4-dependent hypothalamic inflammation. Journal of Hazardous Materials, 402, 123926. 4. [4] Çelik, Y., and Şahin, S. (2021). Health effects of bisphenol-A as an endocrine disrupting chemical. Journal of Continuing Medical Education, 29(6), 439–445. 5. [5] Rancière, F., Botton, J., Slama, R., Lacroix, M. Z., Debrauwer, L., Charles, M. A., Roussel, R., Balkau, B., Magliano, D. J., and Vol, S. (2019). Exposure to bisphenol -A and bisphenol s and incident type 2 diabetes: A case-cohort study in the French cohort D.E.S.I.R. Environmental Health Perspectives, 127(10), 1–9.
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