Results of a Clinical Trial to Determine the Efficacy, Safety, and Tolerability of Intravenous Drip Infusion Therapy of a New Epoprostenol Formulation in Japanese Children with Pulmonary Arterial Hypertension

Author:

Saji Tsutomu1,Yamada Osamu2,Doi Shozaburo3,Yamagishi Hiroyuki4,Hatta Motonori5,Yokoyama Yoshinari5

Affiliation:

1. Advanced and Integrated Cardiovascular Research Course in the Young and Adolescence, Toho University

2. Department of Pediatrics, National Cerebral and Cardiovascular Center

3. Department of Pediatrics, Perinatal and Maternal Medicine, Tokyo Medical and Dental University, Graduate School

4. Department of Pediatrics, Keio University School of Medicine

5. Research and Development, Actelion Pharmaceuticals Japan Ltd.

Publisher

The Japanese Society of Pediatric Cardiology and Cardiac Surgery

Subject

Polymers and Plastics,General Environmental Science

Reference18 articles.

1. 1) Pietra GG, Capron F, Stewart S, et al: Pathologic assessment of vasculopathies in pulmonary hypertension. J Am Coll Cardiol 2004; 43 Suppl S: 25S–32S

2. 2) Chin KM, Rubin LJ: Pulmonary arterial hypertension. J Am Coll Cardiol 2008; 51: 1527–1538

3. 4) Ivy DD, Abman SH, Barst RJ, et al: Pediatric pulmonary hypertension. J Am Coll Cardiol 2013; 62 Suppl: D117–D126

4. 5) Abman SH, Hansmann G, Archer SL, et al: Pediatric pulmonary hypertension: Guidelines from the American Heart Association and American Thoracic Society. Circulation 2015; 132: 2037–2099

5. 6) Galiè N, Humbert M, Vachiery JL, et al: 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur Heart J 2016; 37: 67–119

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