Statistical Methods in Integrative Genomics

Abstract

Statistical methods in integrative genomics aim to answer important biology questions by jointly analyzing multiple types of genomic data (vertical integration) or aggregating the same type of data across multiple studies (horizontal integration). In this article, we introduce different types of genomic data and data resources, and then we review statistical methods of integrative genomics with emphasis on the motivation and rationale of these methods. We conclude with some summary points and future research directions.