WNT and β-Catenin in Cancer: Genes and Therapy

Author:

Jackstadt Rene1,Hodder Michael Charles1,Sansom Owen James12

Affiliation:

1. Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom;

2. Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom

Abstract

The WNT pathway is a pleiotropic signaling pathway that controls developmental processes, tissue homeostasis, and cancer. The WNT pathway is commonly mutated in many cancers, leading to widespread research into the role of WNT signaling in carcinogenesis. Understanding which cancers are reliant upon WNT activation and which components of the WNT signaling pathway are mutated is paramount to advancing therapeutic strategies. In addition, building holistic insights into the role of WNT signaling in not only tumor cells but also the tumor microenvironment is a vital area of research and may be a promising therapeutic strategy in multiple immunologically inert cancers. Novel compounds aimed at modulating the WNT signaling pathway using diverse mechanisms are currently under investigation in preclinical/early clinical studies. Here, we review how the WNT pathway is activated in multiple cancers and discuss current strategies to target aberrant WNT signaling.

Publisher

Annual Reviews

Subject

Cancer Research,Cell Biology,Oncology

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