Mechanisms of Autophagy-Reference-Cited by-同舟云学术

Mechanisms of Autophagy

Published:2015-06-22 Issue:1 Volume:44 Page:101-122
ISSN:1936-122X
Container-title:Annual Review of Biophysics
language:en
Short-container-title:Annu. Rev. Biophys.

Author:

Noda Nobuo N.¹²,Inagaki Fuyuhiko²³

Affiliation:

1. Institute of Microbial Chemistry (BIKAKEN), Tokyo 141-0021, Japan;

2. CREST, Japan Science and Technology Agency, 7, Gobancho, Chiyoda-ku, Tokyo 102-0076, Japan

3. Faculty of Advanced Life Science, Hokkaido University, Sapporo 001-0021, Japan;

Abstract

The formation of the autophagosome, a landmark event in autophagy, is accomplished by the concerted actions of Atg proteins. The initial step of starvation-induced autophagy in yeast is the assembly of the Atg1 complex, which, with the help of other Atg groups, recruits Atg conjugation systems and initiates the formation of the autophagosome. In this review, we describe from a structural-biological point of view the structure, interaction, and molecular roles of Atg proteins, especially those in the Atg1 complex and in the Atg conjugation systems.

Publisher

Annual Reviews

Subject

Cell Biology,Biochemistry,Bioengineering,Structural Biology,Biophysics

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev-biophys-060414-034248

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