Glucose-Dependent Insulinotropic Polypeptide—A Postprandial Hormone with Unharnessed Metabolic Potential-Reference-Cited by-同舟云学术

Glucose-Dependent Insulinotropic Polypeptide—A Postprandial Hormone with Unharnessed Metabolic Potential

Published:2022-08-22 Issue:1 Volume:42 Page:21-44
ISSN:0199-9885
Container-title:Annual Review of Nutrition
language:en
Short-container-title:Annu. Rev. Nutr.

Author:

Guccio Nunzio¹,Gribble Fiona M.¹,Reimann Frank¹

Affiliation:

1. MRC Metabolic Diseases Unit, Wellcome Trust/MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom;,

Abstract

Glucose-dependent insulinotropic polypeptide (GIP) is released from the upper small intestine in response to food intake and contributes to the postprandial control of nutrient disposition, including of sugars and fats. Long neglected as a potential therapeutic target, the GIPR axis has received increasing interest recently, with the emerging data demonstrating the metabolically favorable outcomes of adding GIPR agonism to GLP-1 receptor agonists in people with type 2 diabetes and obesity. This review examines the physiology of the GIP axis, from the mechanisms underlying GIP secretion from the intestine to its action on target tissues and therapeutic development.

Publisher

Annual Reviews

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev-nutr-062320-113625

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