Inflammatory Caspases: Toward a Unified Model for Caspase Activation by Inflammasomes

Author:

Ross Connie12,Chan Amy H.1,von Pein Jessica B.1,Maddugoda Madhavi P.1,Boucher Dave3,Schroder Kate1

Affiliation:

1. Institute for Molecular Bioscience and IMB Centre for Inflammation and Disease Research, The University of Queensland, St. Lucia, Australia;

2. Current affiliation: School of Chemistry and Molecular Sciences, The University of Queensland, St. Lucia, Australia

3. York Biomedical Research Institute, Department of Biology, University of York, York, United Kingdom

Abstract

Inflammasomes are inflammatory signaling complexes that provide molecular platforms to activate the protease function of inflammatory caspases. Caspases-1, -4, -5, and -11 are inflammatory caspases activated by inflammasomes to drive lytic cell death and inflammatory mediator production, thereby activating host-protective and pathological immune responses. Here, we comprehensively review the mechanisms that govern the activity of inflammatory caspases. We discuss inflammatory caspase activation and deactivation mechanisms, alongside the physiological importance of caspase activity kinetics. We also examine mechanisms of caspase substrate selection and how inflammasome and cell identities influence caspase activity and resultant inflammatory and pyroptotic cellular programs. Understanding how inflammatory caspases are regulated may offer new strategies for treating infection and inflammasome-driven disease.

Publisher

Annual Reviews

Subject

Immunology,Immunology and Allergy

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