The Role of Atg Proteins in Autophagosome Formation-Reference-Cited by-同舟云学术

The Role of Atg Proteins in Autophagosome Formation

Published:2011-11-10 Issue:1 Volume:27 Page:107-132
ISSN:1081-0706
Container-title:Annual Review of Cell and Developmental Biology
language:en
Short-container-title:Annu. Rev. Cell Dev. Biol.

Author:

Mizushima Noboru¹,Yoshimori Tamotsu²,Ohsumi Yoshinori³

Affiliation:

1. Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan;

2. Department of Genetics, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan;

3. Frontier Research Center, Tokyo Institute of Technology, Yokohama 226-8503, Japan;

Abstract

Macroautophagy is mediated by a unique organelle, the autophagosome, which encloses a portion of cytoplasm for delivery to the lysosome. Autophagosome formation is dynamically regulated by starvation and other stresses and involves complicated membrane reorganization. Since the discovery of yeast Atg-related proteins, autophagosome formation has been dissected at the molecular level. In this review we describe the molecular mechanism of autophagosome formation with particular focus on the function of Atg proteins and the long-standing discussion regarding the origin of the autophagosome membrane.

Publisher

Annual Reviews

Subject

Cell Biology,Developmental Biology

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev-cellbio-092910-154005

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