Importance of the Major Histocompatibility Complex (Swine Leukocyte Antigen) in Swine Health and Biomedical Research

Author:

Hammer Sabine E.1,Ho Chak-Sum2,Ando Asako3,Rogel-Gaillard Claire4,Charles Mathieu4,Tector Matthew56,Tector A. Joseph57,Lunney Joan K.8

Affiliation:

1. Institute of Immunology, Department of Pathobiology, University of Veterinary Medicine Vienna, A-1210 Vienna, Austria

2. Gift of Hope Organ & Tissue Donor Network, Itasca, Illinois 60143, USA

3. Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Isehara 259-1193, Japan

4. GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France

5. Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA

6. Current address: Makana Therapeutics, Wilmington, Delaware 19801, USA

7. Current address: Department of Surgery, University of Miami, Miami, Florida 33136, USA

8. Animal Parasitic Diseases Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, Maryland 20705, USA;

Abstract

In pigs, the major histocompatibility complex (MHC), or swine leukocyte antigen (SLA) complex, maps to Sus scrofa chromosome 7. It consists of three regions, the class I and class III regions mapping to 7p1.1 and the class II region mapping to 7q1.1. The swine MHC is divided by the centromere, which is unique among mammals studied to date. The SLA complexspans between 2.4 and 2.7 Mb, depending on haplotype, and encodes approximately 150 loci, with at least 120 genes predicted to be functional. Here we update the whole SLA complex based on the Sscrofa11.1 build and annotate the organization for all recognized SLA genes and their allelic sequences. We present SLA nomenclature and typing methods and discuss the expression of SLA proteins, as well as their role in antigen presentation and immune, disease, and vaccine responses. Finally, we explore the role of SLA genes in transplantation and xenotransplantation and their importance in swine biomedical models.

Publisher

Annual Reviews

Subject

General Veterinary,Genetics,Animal Science and Zoology,Biotechnology

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