Reprogrammed Cells for Disease Modeling and Regenerative Medicine-Reference-Cited by-同舟云学术

Reprogrammed Cells for Disease Modeling and Regenerative Medicine

Published:2013-01-14 Issue:1 Volume:64 Page:277-290
ISSN:0066-4219
Container-title:Annual Review of Medicine
language:en
Short-container-title:Annu. Rev. Med.

Author:

Cherry Anne B.C.¹²³,Daley George Q.¹⁴²⁵³

Affiliation:

1. Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Boston Children's Hospital and Dana Farber Cancer Institute;

2. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School;

3. Harvard Stem Cell Institute; Boston, Massachusetts 02115;

4. Division of Hematology, Brigham and Women's Hospital;

5. Broad Institute;

Abstract

The conversion of somatic cells into pluripotent cells is transforming the way diseases are researched and treated. Induced pluripotent stem (iPS) cells' promise may soon be realized in the field of hematology, as hematopoietic stem cell transplants are already commonplace in clinics around the world. We provide a current comparison between induced pluripotent and embryonic stem cells, describe progress toward modeling hematological disorders using iPS cells, and illustrate the hurdles that must be overcome before iPS cell therapies will be available in clinics.

Publisher

Annual Reviews

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev-med-050311-163324

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