RAGs and Regulation of Autoantibodies-Reference-Cited by-同舟云学术

RAGs and Regulation of Autoantibodies

Published:2004-04-01 Issue:1 Volume:22 Page:485-501
ISSN:0732-0582
Container-title:Annual Review of Immunology
language:en
Short-container-title:Annu. Rev. Immunol.

Author:

Jankovic Mila¹,Casellas Rafael²,Yannoutsos Nikos¹,Wardemann Hedda¹,Nussenzweig Michel C.¹³

Affiliation:

1. Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10021;

2. Division of Biology, California Institute of Technology, Pasadena, California 91125;

3. Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021;

Abstract

▪ Abstract Autoreactive antibodies are etiologic agents in a number of autoimmune diseases. Like all other antibodies these antibodies are produced in developing B cells by V(D)J recombination in the bone marrow. Three mechanisms regulate autoreactive B cells: deletion, receptor editing, and anergy. Here we review the prevalence of autoantibodies in the initial antibody repertoire, their regulation by receptor editing, and the role of the recombinase proteins (RAG1 and RAG2) in this process.

Publisher

Annual Reviews

Subject

Immunology,Immunology and Allergy

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev.immunol.22.012703.104707

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