GENETIC DISORDERS OF PROGRAMMED CELL DEATH IN THE IMMUNE SYSTEM-Reference-Cited by-同舟云学术

GENETIC DISORDERS OF PROGRAMMED CELL DEATH IN THE IMMUNE SYSTEM

Published:2006-04-01 Issue:1 Volume:24 Page:321-352
ISSN:0732-0582
Container-title:Annual Review of Immunology
language:en
Short-container-title:Annu. Rev. Immunol.

Author:

Bidère Nicolas¹,Su Helen C.¹,Lenardo Michael J.¹

Affiliation:

1. Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892;

Abstract

Human genetics offers new possibilities for understanding physiological regulatory mechanisms and disorders of the immune system. Genetic abnormalities of lymphocyte cell death programs have provided insights into mechanisms of receptor biology and principles of immune homeostasis and tolerance. Thus far, there are two major diseases of programmed cell death associated with inherited human mutations: the autoimmune lymphoproliferative syndrome and the caspase-eight deficiency state. We describe the details of their molecular pathogenesis and discuss how these diseases illustrate important concepts in immune regulation and genetics.

Publisher

Annual Reviews

Subject

Immunology,Immunology and Allergy

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev.immunol.24.021605.090513

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