Pathophysiological Role of Cytokines in Congestive Heart Failure-Reference-Cited by-同舟云学术

Pathophysiological Role of Cytokines in Congestive Heart Failure

Published:2001-02 Issue:1 Volume:52 Page:15-27
ISSN:0066-4219
Container-title:Annual Review of Medicine
language:en
Short-container-title:Annu. Rev. Med.

Author:

Blum Arnon¹²,Miller Hylton¹²

Affiliation:

1. Department of Internal Medicine, Poria Hospital, Lower Galilee 15208, Israel;

2. Catheterization Laboratory, Department of Cardiology, Tel–Aviv Sourasky Medical Center, 6 Weitzman Street, Tel–Aviv 64239, Israel;

Abstract

▪ Abstract Heart failure is a complex neurohumoral and inflammatory syndrome. Recent studies have shown that proinflammatory cytokines (interleukin-1, interleukin-2, interleukin-6, interleukin-10, and tumor necrosis factor) are involved in cardiac depression and in the complex syndrome of heart failure. Understanding the involvement of these cytokines may enable us to reverse cardiac depression and heart failure by the use of monoclonal antibodies directed against specific cytokines to block the downhill progression of heart failure.

Publisher

Annual Reviews

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev.med.52.1.15

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