Affiliation:
1. Department of Nutrition, Nestlé Research Center, CH-1000 Lausanne 26, Switzerland;
2. Departments of Medicine/GI & Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232;
Abstract
▪ Abstract Cyclooxygenase (COX), also known as prostaglandin endoperoxide synthase, is the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two COX isoforms have been identified, COX-1 and COX-2. In many situations, the COX-1 enzyme is produced constitutively (e.g., in gastric mucosa), whereas COX-2 is highly inducible (e.g., at sites of inflammation and cancer). Traditional nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both enzymes, and a new class of COX-2 selective inhibitors (COXIBs) preferentially inhibit the COX-2 enzyme. This review summarizes our current understanding of the role of COX-1 and COX-2 in normal physiology and disease.
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Cited by
549 articles.
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