THE RISE AND FALL OF MENOPAUSAL HORMONE THERAPY

Author:

Barrett-Connor Elizabeth1,Grady Deborah2,Stefanick Marcia L.3

Affiliation:

1. Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California 92093-0607;

2. Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94105;

3. Stanford Prevention Research Center, School of Medicine, Stanford University, Stanford, California 94305;

Abstract

▪ Abstract  Clinical trials show that hormone therapy (HT) is an effective treatment for vasomotor symptoms and vaginal dryness. HT improves other symptoms including sleep and quality of life in women who have menopause symptoms. In the Women's Health Initiative controlled clinical trials, both estrogen therapy (ET) and estrogen plus progestin therapy (EPT) reduced fracture risk, neither reduced the risk of heart disease, and both increased the risk of stroke, deep vein thrombosis, and dementia. EPT, but not ET, increased breast cancer risk and reduced colon cancer risk. Differences between EPT and ET may reflect chance, baseline differences between the EPT and ET cohorts, or a progestin effect. Studies of younger women and lower HT doses with intermediate endpoints are beginning.

Publisher

Annual Reviews

Subject

Public Health, Environmental and Occupational Health,General Medicine

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