COMPARATIVE DNA ANALYSIS ACROSS DIVERSE GENOMES

Author:

Karlin Samuel1,Campbell Allan M.1,Mrázek Jan1

Affiliation:

1. Department of Mathematics and 2Department of Biological Sciences, Stanford University, Stanford, California 94305-2125

Abstract

▪ Abstract  We review concepts and methods for comparative analysis of complete genomes including assessments of genomic compositional contrasts based on dinucleotide and tetranucleotide relative abundance values, identifications of rare and frequent oligonucleotides, evaluations and interpretations of codon biases in several large prokaryotic genomes, and characterizations of compositional asymmetry between the two DNA strands in certain bacterial genomes. The discussion also covers means for identifying alien (e.g. laterally transferred) genes and detecting potential specialization islands in bacterial genomes.

Publisher

Annual Reviews

Subject

Genetics

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