In vitro and in silico antioxidant and antimicrobial activity of ethanolic extracts of Cnidoscolus cha-yamansa leaves.
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Published:2024-05-13
Issue:
Volume:26
Page:306-314
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ISSN:1665-1456
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Container-title:Biotecnia
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language:
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Short-container-title:BIOTECNIA
Author:
Posada-Mayorga Karla Yesenia,Ruiz-Ruiz Jorge Carlos,Olivo-Vidal Zendy Evelyn,Lobato-Tapia Carlos Alberto,Pacheco-López Neith Aracely,Herrera-Pool Iván Emmanuel,Irecta Najera Cesar Antonio,Sánchez Chino Xariss Miryam
Abstract
Cnidoscolus chayamansa leaves ―used in gastronomy and traditional medicine in Mexico ―are rich in phenolic compounds, which may have antioxidant and antimicrobial activity. In this study we evaluate the antioxidant activity in vitro, and antibacterial activity in silico of ethanolic extracts of C. chayamansa leaves obtained by ultrasonication. Phenolic content was 14.37 mg GAE/ml. Guanosine nucleoside and coumaric acid, and kaempferol derivatives were identified through UPLC-PDA-ESI-MS. Evidence of antioxidant activity was demonstrated by the Cu2+ chelation activity (65.53 %) and the Fe3+ reducing antioxidant power (69.59 %). Although no antibacterial activity was found against E. coli and S. aureus, the in silico analysis revealed that the isolated phenolic compounds modify signalling pathways essential for the survival of the bacteria studied.
Publisher
Universidad de Sonora
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