Complex Regional Pain Syndrome: A different point of view

Abstract

Complex Regional Pain Syndrome (CRPS) is a disease that significantly reduces functional ability and is characterized by pronounced, persistent pain, which often affects one limb. Despite advances in research and treatment, CRPS remains a challenge to diagnose and treat effectively. CRPS mostly affects people between the ages of 40 and 60, with a higher prevalence in women. The pathophysiology of CRPS includes a complex interplay of neuroimmunological, neuroplastic and nociceptive mechanisms. CRPS is characterized by a diverse spectrum of clinical manifestations that reflect a complex interaction of sensory, motor, autonomic, and inflammatory processes. The diagnosis of CRPS requires a multimodal approach that integrates clinical evaluation, diagnostic criteria, and additional testing. The Budapest criteria represent standardized diagnostic criteria, including sensory, motor, vasomotor and sudomotor symptoms. The therapeutic approach to CRPS includes a variety of therapeutic modalities aimed at alleviating pain, improving function, and improving quality of life. A multimodal interdisciplinary approach including pharmacological, non-pharmacological and interventional modalities is necessary for comprehensive treatment. Further research is needed to elucidate the underlying mechanisms and optimize therapeutic strategies for patients with CRPS. This review paper aims to provide a thorough analysis of CRPS, incorporating current research findings to advance understanding and inform evidence-based treatment strategies.