Raman fl uorescence technologies for early detection of infl ammatory and oncological disorders as a part of public health strategy and a tool for improving the quality of medical care: a review

Abstract

The increasing morbidity and mortality rate in inflammatory and oncological diseases requires determining the public health strategies for early  detection of such disorders and improving the quality of medical care. For this goal, high-tech modalities with high sensitivity, specificity and  accuracy are to be worked out. Rаman fluorescent medical technologies (RFMT) can be successfully applied in the diagnostics of inflammatory  and tumor diseases if to develop a specific algorithm for express analysis of histological, physiological, microbiological and other components  of biological tissues. The given article presents a brief overview on the application of Raman fluorescence spectrometry in the diagnostics  of diseases. This medical technology, which utilizes the phenomenon of tissue autoflorescence and Raman light scattering, is a promising  tool for early diagnostics of different inflammatory and oncological pathologies. The described nоn-invasive method allows to make an express  assessment of metabolic, morphometric and functional tissue parameters in intact and in pathological tissue. The present discussion is aimed  to find out points for the application of Rаman fluorescence spectrometry and its various modifications; to assess its potentials for screening;  to develop a specific algorithm for the diagnostics of inflammatory and tumor pathologies. RFMT is a promising modality for future applications  so as to improve the quality of medical care by early detection of inflammatory and tumor diseases and early prescription of rational therapy.