New aspects of the influence of immunity and microbiome on heart transplant rejection

Author:

Golovkin A. S.1ORCID,Kudryavtsev I. V.2ORCID,Fedotov P. A.1ORCID,Kalinina O. V.1ORCID

Affiliation:

1. Almazov National Medical Research Center

2. Almazov National Medical Research Center; Institute of Experimental Medicine

Abstract

Currently, heart transplantation is the key treatment for patients with end-stage heart failure. At the same time, the immunopathogenesis of chronic allograft rejection, which is a key factor in the long-term outcome, is still poorly understood, which, in turn, explains the absence of effective non-invasive methods for its detection. This review discusses up-to-date aspects of the interaction between the microbiota and immune system factors leading to inflammation and T-cell polarization, and their participation in heart transplant rejection. Special attention is paid to the role of microvesicles in immune response modulation within heart transplant rejection.

Publisher

Silicea - Poligraf, LLC

Subject

Cardiology and Cardiovascular Medicine

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