Pleiotropic effect of the ABCA1 rs2230806 polymorphism in cardiovascular diseases: a literature review

Author:

Chernova A. A.1ORCID,Nikulin D. A.1ORCID,Nikulina S. Yu.2ORCID,Maksimov V. N.3ORCID

Affiliation:

1. V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; Federal Siberian Research Clinical Center

2. V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University

3. Research Institute of Internal and Preventive Medicine — a branch of the Federal Research Center Institute of Cytology and Genetics

Abstract

Cerebrovascular accident (CVA) in patients with various cardiovascular diseases is a life-threatening complication, the development of which can be contributed by both environmental and genetic factors, the understanding of which is necessary to determine the tactics of treatment and predict the disease course. The article presents a brief review of studies on genetic predictors of CVA, in particular the association of the ABCA1 rs2230806 polymorphism and the risk of CVA in cardiovascular patients. Targeted studies of associations of the ABCA1 rs2230806 polymorphism with cerebrovascular diseases in the Russian Federation, except for studies at our university, could not be found.

Publisher

Silicea - Poligraf, LLC

Subject

Cardiology and Cardiovascular Medicine

Reference20 articles.

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3. Smirnov GP, Rozhkova TA, Zybareva My, et al. The impact of the allelic variant rs2230806 of the АВСА1 gene on phenotypic expression of familial hypercholesterolemia. Journal of Atherosclerosis and Dyslipidemias. 2018;4(33):36-42. (In Russ.)

4. Ghaznavi H, Aali E, Soltanpour MS. Association Study of the ATP — Binding Cassette Transporter A1 (ABCA1) Rs2230806 Genetic Variation with Lipid Profile and Coronary Artery Disease Risk in an Iranian Population. Open Access Maced J Med Sci. 2018;6(2):274-9. doi:10.3889/oamjms.2018.063.

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