Linaclotide activates guanylate cyclase-C/cGMP/protein kinase-II-dependent trafficking of CFTR in the intestine-Reference-Cited by-同舟云学术

Linaclotide activates guanylate cyclase-C/cGMP/protein kinase-II-dependent trafficking of CFTR in the intestine

Published:2017-06 Issue:11 Volume:5 Page:e13299
ISSN:2051-817X
Container-title:Physiological Reports
language:en
Short-container-title:Physiol Rep

Author:

Ahsan Md. Kaimul¹,Tchernychev Boris²,Kessler Marco M.²,Solinga Robert M.²,Arthur David³,Linde Cristina I.³,Silos-Santiago Inmaculada⁴,Hannig Gerhard²,Ameen Nadia A.¹⁵

Affiliation:

1. Department of Pediatrics/Gastroenterology and Hepatology; Yale School of Medicine; New Haven Connecticut

2. Department of Pharmacology; Ironwood Pharmaceuticals; Cambridge Massachusetts

3. Biopta Ltd; Glasgow United Kingdom

4. Department of Preclinical Research; Decibel Therapeutics; Boston Massachusetts

5. Department of Cellular and Molecular Physiology; Yale School of Medicine; New Haven Connecticut

Funder

National Institutes of Health

Ironwood Inc.

Publisher

Wiley

Subject

Physiology (medical),Physiology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.14814/phy2.13299/fullpdf

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2. Mechanism of Linaclotide-induced Trafficking of CFTR and NHE3 in the Human Intestinal Cell-lines Caco-2 BBe and T84 cells;Ahsan;Faseb J.,2015

3. Defective CFTR apical endocytosis and enterocyte brush border in myosin VI-deficient mice;Ameen;Traffic,2007

4. Subcellular distribution of CFTR in rat intestine supports a physiologic role for CFTR regulation by vesicle traffic;Ameen;Histochem. Cell Biol.,2000

5. cAMP-dependent exocytosis and vesicle traffic regulate CFTR and fluid transport in rat jejunum in vivo;Ameen;Am. J. Physiol. Cell Physiol.,2003

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